APIPL – Manufacturing

Apotex Pharmachem, India
A member of the Apotex Pharmachem Group

APIPL has a multipurpose plant with an operating volume capacity of 25 litres to 3000 litres and a total installed capacity of 31000 litres. With six work centers, we can handle six different active pharmaceutical ingredients simultaneously. This facility has been designed to ensure maximum flexibility and to carry out a wide variety of chemistries while maintaining cGMP compliance.

The details of the facility are as follows:

1. Kilo lab: Two sets with three reactors each.

  • Kilo lab 1: Dedicated facility for handling class III products.
  • Kilo lab 2: For handling high value, low volume APIs.

2. Production blocks

  • Production block 1: Equipped with 12 reactors of capacity ranging 250 L to 1000 L.
  • Production block 2: Equipped with 14 reactors of capacity ranging 500 L to 3000 L.

Innovation and speed are central in our approach to APIPL production; we are adept at devising technological solutions to satisfy unique and challenging customer requirements.

Plant Capabilities

  • Standard Operating Temperature Range: - 15 °C to 140 °C
  • High pressure/high vacuum operating ranges
  • Low & High Temperatures Capability from: –80 °C to 150 °C
  • High containment procedures for potent APIs
  • Solvent recovery and recycling

APIPL drying and material handling areas are built to class 100,000 clean room specifications. Three product drying technologies are currently in use: vacuum tray, vacuum rotary cone and fluid bed. Other special novel polymorph control equipment such as freeze drier and spray drier are used.

At APIPL, different size reduction techniques are being followed using equipment such as multi mill, colloidal mill, micronization and jet milling in order to achieve customer’s particle size requirements.

 

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